Double-blind evaluation of intradiscal chymopapain for herniated lumbar discs. Early results.

@article{Schwetschenau1976DoubleblindEO,
  title={Double-blind evaluation of intradiscal chymopapain for herniated lumbar discs. Early results.},
  author={P R Schwetschenau and Agust{\'i}n Jos{\'e} Ramirez and Jane Louise Johnston and Cheri Wiggs and Alex Martins},
  journal={Journal of neurosurgery},
  year={1976},
  volume={45 6},
  pages={
          622-7
        }
}
The authors report 66 patients with signs, symptoms, and a myelographic abnormality of herniated lumbar disc, who were not responsive to conservative treatment. The discs were injected at random with either chymopapain or a placebo. Neither patient nor surgeon knew which agent was used until after the results had been tabulated. Unless early laminectomy was necessary for intractable pain, all patients were followed for 2 months or more. There was no statistically significant difference in… CONTINUE READING

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