Double-blind cross-over placebo controlled study of flunarizine in patients with therapy resistant epilepsy.

@article{Starreveld1989DoubleblindCP,
  title={Double-blind cross-over placebo controlled study of flunarizine in patients with therapy resistant epilepsy.},
  author={E Starreveld and F de Beukelaar and Archie F. Wilson and Donald R. McLean and H. Findlay},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  year={1989},
  volume={16 2},
  pages={187-90}
}
Twenty-five patients with long-standing therapy resistant epilepsy were studied in an eight-month double-blind cross-over add-on trial with a daily dose of 15 mg flunarizine. In five patients the seizure frequency decreased 50% or more. The mean seizure frequency reduction in the patients on flunarizine was 35%. Particularly the control of secondary generalized seizures improved. Flunarizine did not significantly alter the plasma levels of the regular anticonvulsant drugs. Minimal adverse side… CONTINUE READING

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