Double-blind comparison of an acetaminophen 400 mg-codeine 25 mg combination versus aspirin 1000 mg and placebo in acute migraine attack.

@article{Boureau1994DoubleblindCO,
  title={Double-blind comparison of an acetaminophen 400 mg-codeine 25 mg combination versus aspirin 1000 mg and placebo in acute migraine attack.},
  author={François Boureau and J. H. M. Joubert and Virginie Lasserre and Bruce E. Prum and G Delecoeuillerie},
  journal={Cephalalgia : an international journal of headache},
  year={1994},
  volume={14 2},
  pages={156-61}
}
The purpose of this study was to compare the efficacy and tolerance of a single dose of the acetaminophen 400 mg-codeine 25 mg combination (ACC) aspirin 1000 mg (A) and a placebo (P) for the treatment of acute migraine attack. The study design was randomized, multicentre, double-blind and double dummy with cross-over on three periods. Of the 198 patients who had three attacks 29.8%, 52.3% and 49.7% had recorded the complete or almost complete disappearance of the pain at 2 h after P, A and ACC… CONTINUE READING