Double blind, randomized, placebo controlled clinical trial of methotrexate in systemic lupus erythematosus.

@article{Carneiro1999DoubleBR,
  title={Double blind, randomized, placebo controlled clinical trial of methotrexate in systemic lupus erythematosus.},
  author={Jo{\~a}o R{\'e}gis Ivar Carneiro and Em{\'i}lia Inoue Sato},
  journal={The Journal of rheumatology},
  year={1999},
  volume={26 6},
  pages={1275-9}
}
OBJECTIVE To evaluate the capacity of methotrexate (MTX) to control mild activity of systemic lupus erythematosus (SLE), and to evaluate the capacity of MTX to reduce steroid requirement, as well as to evaluate the side effects of MTX in patients with SLE. METHODS A prospective, randomized, controlled, double blind trial. Forty-one patients with SLE began and 37 completed the 6 months of study. The mean disease duration was 82.5 months. Twenty patients received MTX 15-20 mg/week (MTX group… CONTINUE READING
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