• Corpus ID: 6500315

Double-blind, randomized, acyclovir-controlled, parallel-group trial comparing the safety and efficacy of famciclovir and acyclovir in patients with uncomplicated herpes zoster.

@article{Shen2004DoubleblindRA,
  title={Double-blind, randomized, acyclovir-controlled, parallel-group trial comparing the safety and efficacy of famciclovir and acyclovir in patients with uncomplicated herpes zoster.},
  author={Meng-Chuan Shen and Hsi‐Hsun Lin and Susan Shin-Jung Lee and Yao Shen Chen and Ping-Chen Chiang and Yung-ching Liu},
  journal={Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi},
  year={2004},
  volume={37 2},
  pages={
          75-81
        }
}
This randomized, double-blind, parallel-group study compared the efficacy and safety of famciclovir administered at 250 mg thrice daily with acyclovir 800 mg 5 times daily for the treatment of acute uncomplicated herpes zoster in immunocompetent adults. [] Key Result A total of 55 patients participated in this trial. Twenty seven patients (49.1%) were randomized into the famciclovir plus placebo treatment group and 28 (50.9%) into the acyclovir plus placebo group.

Figures and Tables from this paper

A comparative study to evaluate the efficacy and safety of acyclovir and famciclovir in the management of herpes zoster.

Oral famciclovir administered three times daily for 7 days during acute zoster infection is as effective as acyclovir, administered 800mg five times daily and offers significant benefit by providing a well tolerated, cost effective, convenient dosage regime and accelerated rate of lesion resolution and a reduced duration of PHN.

A Comparative Study Of Famciclovir Versus Acyclovir In The Treatment Of Herpes Zoster

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Comparative Study of Oral Acyclovir and Oral Famciclovir in the treatment of Herpes Zoster

Famciclovir can be a better option in the treatment of herpes zoster in view of all the above mentioned facts and it has got a convenient dosage schedule as well.

Pharmacokinetics and Safety of Famciclovir in Children with Herpes Simplex or Varicella-Zoster Virus Infection

An eight-step weight-based dosing regimen was developed to optimize exposure in smaller children and was used in the 7-day multiple-dose safety phases of both studies, which enrolled 100 patients with confirmed/suspected viral infections.

Antivirals for Management of Herpes Zoster Including Ophthalmicus: A Systematic Review of High-Quality Randomized Controlled Trials

Evidence from quality trials have shown significant reduction in risk of pain with valaciclovir and famciclovIR for management of herpes zoster including ophthalmicus.

Single-Dose Pharmacokinetics of Famciclovir in Infants and Population Pharmacokinetic Analysis in Infants and Children

The data suggested that the dose administered to infants <6 months was less than optimal, and an eight-step dosing regimen was derived that targeted exposure in infants and children 6 months to 12 years of age to match the penciclovir AUC seen in adults after a 500-mg dose of famcic Lovir.

Treatment of herpes zoster.

There is no convincing evidence that antiviral medication reduces the risk of PHN, and these drugs should be prescribed to all patients at the first signs of ophthalmic HZ, irrespective of age or severity of symptoms.

Current Management of Herpes Zoster

Use of antiviral therapy including the newer potent antiviral agents such as brivudin, which requires less frequent administration than acyclovir, is improving patient outcomes in some European countries and, as a result, overall antiviral use is low.

Efficacy of famciclovir in the treatment of oral hairy leukoplakia

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Confidence intervals are important but underused supplements to tests of significance for reporting the results of clinical investigations, and formulas are presented for calculating confidence intervals with types of data commonly found in clinical trials.