Double-blind, placebo-controlled trial of clonidine in hyperactive children with mental retardation.

@article{Agarwal2001DoubleblindPT,
  title={Double-blind, placebo-controlled trial of clonidine in hyperactive children with mental retardation.},
  author={Vivek Agarwal and Prabhat Sitholey and Sudhanshu Kumar and Maya Prasad},
  journal={Mental retardation},
  year={2001},
  volume={39 4},
  pages={259-67}
}
A 12-week, double-blind, randomized, placebo-controlled trial of oral clonidine in three fixed doses (4, 6, and 8 mcg/kg/day) using a crossover design was conducted with 10 children who had hyperkinetic disorder (mean age 7.6 years +/-.54). All had comorbid mental retardation. Both parents' ratings on the Parent Symptom Questionnaire and clinicians' ratings on the Hillside Behaviour Rating Scale showed a marked dose-related response to clonidine in hyperactivity, impulsivity, and inattention… CONTINUE READING

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