Double-blind, placebo controlled comparison of paracetamol and paracetamol plus codeine — a quantitative evaluation by laser induced pain

@article{ArendtNielsen1991DoubleblindPC,
  title={Double-blind, placebo controlled comparison of paracetamol and paracetamol plus codeine — a quantitative evaluation by laser induced pain},
  author={Lars Arendt-Nielsen and Julia Nielsen and Peter J Bjerring},
  journal={European Journal of Clinical Pharmacology},
  year={1991},
  volume={40},
  pages={241-247}
}
The aim of the present double-blind, placebo controlled, three-way cross over study was to evaluate the analgesic efficacy of single oral doses of paracetamol 1.0 g and paracetamol 1.0 g plus codeine 60 mg. Pain threshold and brain evoked potentials to laser stimulation were determined hourly for 6 h in 12 healthy volunteers. Pain threshold was… CONTINUE READING