Double- and monofunctional CD4⁺ and CD8⁺ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals.

@article{Commandeur2011DoubleAM,
  title={Double- and monofunctional CD4⁺ and CD8⁺ T-cell responses to Mycobacterium tuberculosis DosR antigens and peptides in long-term latently infected individuals.},
  author={Susanna Commandeur and May Young Lin and Krista E van Meijgaarden and Annemieke H. Friggen and Kees L M C Franken and Jan Wouter Drijfhout and Gro Ellen Korsvold and Fredrik Oftung and Annemieke Geluk and Tom H. M. Ottenhoff},
  journal={European journal of immunology},
  year={2011},
  volume={41 10},
  pages={2925-36}
}
More than 2 billion individuals are latently infected with Mycobacterium tuberculosis (Mtb). Knowledge of the key Mtb antigens and responding T-cell subsets mediating protection against Mtb is critical for developing improved tuberculosis (TB) vaccines. We previously reported that Mtb DosR-regulon-encoded antigens are recognized well by human T cells in association with control of Mtb infection. The characteristics of the responding T-cell subsets, however, remained unidentified. We have… CONTINUE READING

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