Double Spirocyclization of Arylidene-Δ2-Pyrrolin-4-Ones with 3-Isothiocyanato Oxindoles

@article{Riko2020DoubleSO,
  title={Double Spirocyclization of Arylidene-$\Delta$2-Pyrrolin-4-Ones with 3-Isothiocyanato Oxindoles},
  author={Sebastijan Ri{\vc}ko and Žan Testen and Luka Ciber and Franc Po{\vz}gan and Bogdan {\vS}tefane and Helena Brodnik and Jurij Svete and Uro{\vs} Gro{\vs}elj},
  journal={Catalysts},
  year={2020},
  volume={10},
  pages={1211}
}
Arylidene-Δ2-pyrrolin-4-ones undergo organocatalyzed double spirocyclization with 3-isothiocianato oxindoles in a domino 1,4/1,2-addition sequence. The products contain three contiguous stereocenters (ee up to 98%, dr up to 99:1, 12 examples). The absolute configuration of the major diastereomer was determined by single crystal X-ray analysis. Along with heterocyclic Michael acceptors based on oxazolone, isoxazolone, thiazolidinone, pyrazolone, and pyrimidinedione, the reported results display… 
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