• Corpus ID: 16146162

Double-Outlet Right Ventricle and Overriding Tricuspid Valve Reflect Disturbances of Looping, Myocardialization, Endocardial Cushion Differentiation, and Apoptosis in TGF-b2–Knockout Mice

  title={Double-Outlet Right Ventricle and Overriding Tricuspid Valve Reflect Disturbances of Looping, Myocardialization, Endocardial Cushion Differentiation, and Apoptosis in TGF-b2–Knockout Mice},
  author={Ulrike Bartram and Dani{\"e}l G M Molin and Lambertus J. Wisse and Azhar Mohamad and L. Philip Sanford and Thomas C. Doetschman and Christian Paul Speer and Robert E. Poelmann and Adriana C. Gittenberger-de Groot},
Background—Transforming growth factorb2 (TGF-b2) is a member of a family of growth factors with the potential to modify multiple processes. Mice deficient in the TGFb2 gene die around birth and show a variety of defects of different organs, including the heart. Methods and Results —We studied the hearts of TGFb2–null mouse embryos from 11.5 to 18.5 days of gestation to analyze the types of defects and determine which processes of cardiac morphogenesis are affected by the absence of TGF-b2… 

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