Double-Blind Characterization of Non-Genome-Sequenced Bacteria by Mass Spectrometry-Based Proteomics

  title={Double-Blind Characterization of Non-Genome-Sequenced Bacteria by Mass Spectrometry-Based Proteomics},
  author={Rabih E. Jabbour and Samir V. Deshpande and Mary Margaret Wade and Michael F. Stanford and Charles Wick and Alan W. Zulich and Evan Skowronski and A. Peter Snyder},
  journal={Applied and Environmental Microbiology},
  pages={3637 - 3644}
ABSTRACT Due to the possibility of a biothreat attack on civilian or military installations, a need exists for technologies that can detect and accurately identify pathogens in a near-real-time approach. One technology potentially capable of meeting these needs is a high-throughput mass spectrometry (MS)-based proteomic approach. This approach utilizes the knowledge of amino acid sequences of peptides derived from the proteolysis of proteins as a basis for reliable bacterial identification. To… 
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