Double-Blind , Randomized Study Evaluating the Glycemic and Anti-in fl ammatory Effects of Subcutaneous LY 2189102 , a Neutralizing IL-1 b Antibody , in PatientsWith Type 2 Diabetes

@inproceedings{SloanLancaster2013DoubleBlindR,
  title={Double-Blind , Randomized Study Evaluating the Glycemic and Anti-in fl ammatory Effects of Subcutaneous LY 2189102 , a Neutralizing IL-1 b Antibody , in PatientsWith Type 2 Diabetes},
  author={Joanne Sloan-Lancaster and Eyas Jamal Abu-Raddad and John Patrick Polzer and Jeffrey W. Miller and Joel C. Scherer and Andrea De Gaetano and Jolene Kay Berg and William H. Landschulz},
  year={2013}
}
Type 2 diabetes occurs when pancreatic b-cell function fails to compensate for insulin resistance (1,2). As the duration of diabetes increases, b-cell function progressively deteriorates, partly as a result of apoptotic cell death (3–5). Inflammation is associated with pancreatic b-cell apoptosis and reduced insulin sensitivity, supporting the notion that inflammation plays a key role in aggravating or even causing type 2 diabetes specifically or the metabolic syndrome generally (6… CONTINUE READING

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