Double-Blind, Double-Dummy Comparative Study of Local Action Transcutaneous Flurbiprofen (Flurbiprofen LAT) versus Piketoprofen Cream in the Treatment of Extra-Articular Rheumatism

  title={Double-Blind, Double-Dummy Comparative Study of Local Action Transcutaneous Flurbiprofen (Flurbiprofen LAT) versus Piketoprofen Cream in the Treatment of Extra-Articular Rheumatism},
  author={{\'A}. Burgos and M. P. Busquier and J. G. Reino and J. Ferreiro and F. Navarro and J. Valverde and E. Moreno},
  journal={Clinical Drug Investigation},
ObjectiveA local action transcutaneous (LAT) system has been developed for the topical application of the nonsteroidal anti-inflammatory drug flurbiprofen. The purpose of the present study was to compare the efficacy and tolerability as well as the patients’ acceptance of flurbiprofen LAT versus the cream formulation of piketoprofen in the treatment of patients with soft tissue rheumatism.Design and SettingThis was a multicentre, randomised, double-blind, double-dummy, parallel group study… Expand
8 Citations
Non-steroidal anti-inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults.
Low-quality and conflicting evidence regarding the benefits of oral NSAIDs obtained from two trials could not be pooled, and low-quality evidence was obtained from three trials suggesting that topical NSAIDs were significantly more effective than placebo with respect to pain in the short term. Expand
Topical NSAIDs for chronic musculoskeletal pain in adults.
In studies lasting 6 to 12 weeks, topical diclofenac and topical ketoprofen were significantly more effective than carrier for reducing pain; about 60% of participants had much reduced pain. Expand
The efficacy of a local action transcutaneous flurbiprofen patch, in the treatment of lateral epicondylitis
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The relative effectiveness of spinal manipulative therapy combined with transcutaneous flurbiprofen versus spinal manipulative therapy combined with either menthol or non-medicated placebo patches in the management of sacroiliac syndrome
Dissertation submitted in partial compliance with the requirements for a Master's Degree in Technology: Chiropratic, Technikon Natal, 2002.
Comparative Effectiveness and Safety of Analgesics for Osteoarthritis
Under contract to the Agency for Healthcare Research and Quality (AHRQ), Rockville, MD (Contract No. 290-02-0024), the findings and conclusions are those of the authors and do not necessarily represent the views of AHRQ. Expand
Microemulsions as carriers for drugs and nutraceuticals.
It was found that even W/O microemulsions, which are expected to break upon dilution in the digestive tract, increase the permeability and bioavailability of drugs. Expand
Topical NSAIDs for chronic musculoskeletal pain: systematic review and meta-analysis
Topical NSAIDs were effective and safe in treating chronic musculoskeletal conditions for two weeks and larger and longer trials are necessary to fully elucidate the place of topical NSAIDs in clinical practice. Expand


Local action transcutaneous flurbiprofen in the treatment of soft tissue rheumatism.
It is concluded that flurbiprofen LAT is an effective and acceptable treatment for soft tissue lesions, and should be considered as an alternative therapy to local steroid injection. Expand
Pharmacokinetic comparison of oral and local action transcutaneous flurbiprofen in healthy volunteers
The pharmacokinetic parameters for delivery of the drug by both routes were compared and plasma concentrations of flurbiprofen and urinary concentrations of the NSAID and its metabolites were measured by high–performance liquid chromatography assay. Expand
Evaluation of the Efficacy and Tolerability of a New Topical Formulation of Flurbiprofen in Acute Soft Tissue Injuries
It is suggested that the flurbiprofen transcutaneous patch can aid pain relief and quicken the functional recovery from soft tissue injuries. Expand
Flurbiprofen versus Diclofenac for the Treatment of Osteoarthritis of the Knee
The data from this clinical trial tend to support the equiefficacy of 50 mg tid regimens of flurbiprofen versus diclofenac for treating osteoarthritis of the knee. Expand
Quantitive systematic review of topically applied non-steroidal anti-inflammatory drugs
Topical non-steroidal anti-inflammatory drugs are effective in relieving pain in acute and chronic conditions and their effectiveness and safety are widely thought to be ineffective, despite licensed status. Expand
European experience with flurbiprofen. A new analgesic/anti-inflammatory agent.
For patients with rheumatoid arthritis, a review of several trials found flurbiprofen often superior to aspirin and naproxen, and equivalent to indomethacin and ibuprofen in efficacy. Expand
Skin disposition of drugs after topical application in hairless rats.
Cutaneous disposition of model drugs, antipyrine (ANP), lidocaine (LC) and piroxicam (PXC) as well as flurbiprofen (FP) was evaluated in hairless rats in which an agar gel disc was subcutaneously inserted into the abdominal region as a drug receptor and a drug donor cell was placed above it to evaluate skin disposition. Expand
Risk and cost of gastrointestinal side effects associated with nonsteroidal anti-inflammatory drugs.
  • B. Bloom
  • Medicine
  • Archives of internal medicine
  • 1989
The risk and cost of gastrointestinal side effects associated with the use of nonsteroidal anti-inflammatory drugs for an at-risk period from January 1, 1985, through March 31, 1985 was determined. Expand
Efficacy of flurbiprofen for nonarthritic pain
The results of prospective controlled clinical trials have demonstrated flurbiprofen's effectiveness as an analgesic in the nonarthritic conditions of postoperative dental pain, pain following majorExpand
The risks and costs of upper gastrointestinal disease attributable to NSAIDs.
The increased risks for adverse upper GI hemorrhage and peptic ulcer disease associated with NSAID use have been demonstrated in observational studies and clinical trials; an overview of these results is presented. Expand