Dotarizine versus flunarizine as calcium antagonists in chromaffin cells

@article{Villarroya1995DotarizineVF,
  title={Dotarizine versus flunarizine as calcium antagonists in chromaffin cells},
  author={M{\'e}rcedes Villarroya and Luis Gand{\'i}a and Baldomero Lara and Almudena Albillos and Manuela G. L{\'o}pez and Antonio G. Garc{\'i}a},
  journal={British Journal of Pharmacology},
  year={1995},
  volume={114}
}
1 Dotarizine is a novel piperazine derivative structurally related to flunarizine that is currently being evaluated in clinical trials for its antimigraine and antivertigo effects. This clinical profile may be related to its Ca2+ antagonist properties. Therefore, the actions of both compounds as calcium antagonists were compared in bovine chromaffin cells. 2 Dotarizine and flunarizine blocked 45Ca2+ uptake into K+ depolarized chromaffin cells (70 mm K+/0.5 mm Ca2+ for 60 s) in a concentration… 
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