Dosing regimens of cotrimoxazole (trimethoprim-sulfamethoxazole) for melioidosis.

@article{Cheng2009DosingRO,
  title={Dosing regimens of cotrimoxazole (trimethoprim-sulfamethoxazole) for melioidosis.},
  author={Allen C Cheng and Emma Sue McBryde and Vanaporn Wuthiekanun and Wirongrong Chierakul and Premjit Amornchai and Nicholas P J Day and Nicholas J White and Sharon J Peacock},
  journal={Antimicrobial agents and chemotherapy},
  year={2009},
  volume={53 10},
  pages={4193-9}
}
Melioidosis is an infectious disease with a propensity for relapse, despite prolonged antibiotic eradication therapy for 12 to 20 weeks. A pharmacokinetic (PK) simulation study was performed to determine the optimal dosing of cotrimoxazole (trimethoprim-sulfamethoxazole [TMP-SMX]) used in current eradication regimens in Thailand and Australia. Data for bioavailability, protein binding, and coefficients of absorption and elimination were taken from published literature. Apparent volumes of… CONTINUE READING
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