Dosing of antibiotics in critically ill patients: are we left to wander in the dark?

@article{MatuszkiewiczRowiska2012DosingOA,
  title={Dosing of antibiotics in critically ill patients: are we left to wander in the dark?},
  author={Joanna Matuszkiewicz-Rowińska and Jolanta Małyszko and Ewa Wojtaszek and Paweł Kulicki},
  journal={Polskie Archiwum Medycyny Wewnetrznej},
  year={2012},
  volume={122 12},
  pages={
          630-40
        }
}
Critically ill patients are frequently affected by acute kidney injury accompanied by dysfunction of other systems and organs. Sepsis is common in this population and remains a major cause of multiorgan dysfunction syndrome, indicating a crucial role in efficient antibiotic treatment. However, such treatment is particularly difficult due to altered pharmacokinetic profile in these patients, dynamic changes in their clinical status and, in many cases, need for renal replacement therapy (RRT… CONTINUE READING

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