Dosing guidelines for fluconazole in patients with renal failure.

  title={Dosing guidelines for fluconazole in patients with renal failure.},
  author={Lucile Cousin and Marie Le Berre and Vincent Launay-Vacher and Hassane Izzedine and Gilbert Deray},
  journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association},
  volume={18 11},
Fluconazole is a widely used drug that inhibits the synthesis of fungal cell membranes [1,2]. Its elimination is predominantly via renal excretion with most of the dose recovered in urine as an unchanged and active drug. As a result, drug pharmacokinetics are altered in patients with renal failure and it is essential to establish guidelines on how to handle this drug in those patients. Furthermore, in dialysis patients, the removal of the drug in the dialysate has to be elucidated to determine… CONTINUE READING

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