Dosing algorithm revisit for busulfan following IV infusion

  title={Dosing algorithm revisit for busulfan following IV infusion},
  author={Yanlin Wang and Kazunobu Kato and Christopher Le Gallo and Elizabeth Armstrong and Edwin P. Rock and Xiaofeng Wang},
  journal={Cancer Chemotherapy and Pharmacology},
Busulfan (Bu) exposure is critical for efficacy and safety. Body weight (BW), or adjusted ideal body weight (AIBW)-based dosing (WBD) algorithm, has been used in hematopoietic stem cell transplantation (HSCT). A recently completed phase 2 study revealed that 33.6 % of the subjects were under-, or over-exposed, with this WBD algorithm. This paper was to investigate Bu dosing algorithm in an attempt to improve the suboptimal Bu exposure. Population PK modeling was conducted using the data from… CONTINUE READING


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