Dosimetry of chlorinated quinone metabolites of pentachlorophenol in the livers of rats and mice based upon measurement of protein adducts.

Abstract

The dosimetry of chlorinated quinones arising from metabolism of pentachlorophenol (PCP), in the livers of male Sprague-Dawley rats and B6C3F1 mice was investigated via measurements of cysteinyl protein adducts and estimates of the second-order reaction rate constants between the quinones and the proteins. We had previously shown that adducts of tetrachloro… (More)

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