Dosimetric adjustments for interspecies extrapolation of inhaled poorly soluble particles (PSP).

@article{Jarabek2005DosimetricAF,
  title={Dosimetric adjustments for interspecies extrapolation of inhaled poorly soluble particles (PSP).},
  author={Annie M. Jarabek and Bahman Asgharian and Frederick W Miller},
  journal={Inhalation toxicology},
  year={2005},
  volume={17 7-8},
  pages={317-34}
}
Direct calculation of delivered dose in the species of interest potentially affects the magnitude of an uncertainty factor needed to address extrapolation of laboratory animal data to equivalent human exposure scenarios, thereby improving the accuracy of human health risk estimates. Development of an inhalation reference concentration (RfC) typically involves extrapolation of an effect level observed in a laboratory animal exposure study to a level of exposure in humans that is not expected to… CONTINUE READING
26 Citations
74 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 74 references

A mechanistic model of lifetime cancer risk for inhala

  • A M.
  • 2004
Highly Influential
20 Excerpts

The 1994 ICRP66 human respiratory tract model as a tool for predicting lung burdens from exposures to environmental aerosols

  • M. B. Snipes, A. C. James, A. M. Jarabek
  • Appl. Occup. Environ. Hyg. 12(8):547–554.
  • 1997
Highly Influential
9 Excerpts

Consideration of temporal toxicity challenges

  • A. M. Jarabek
  • 1995
Highly Influential
11 Excerpts

A model of deposition of hygroscopic particles

  • B. Asgharian
  • 2004
Highly Influential
3 Excerpts

age - and gender - specific pharmacokinetic differences on tissue dosimetry

  • R. B. Conolly, J. S. Kimbell, +4 authors F. J. Miller
  • Toxicol . Sci .
  • 2003
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…