Dosimetric adjustments for interspecies extrapolation of inhaled poorly soluble particles (PSP).

  title={Dosimetric adjustments for interspecies extrapolation of inhaled poorly soluble particles (PSP).},
  author={Annie M. Jarabek and Bahman Asgharian and Frederick W Miller},
  journal={Inhalation toxicology},
  volume={17 7-8},
Direct calculation of delivered dose in the species of interest potentially affects the magnitude of an uncertainty factor needed to address extrapolation of laboratory animal data to equivalent human exposure scenarios, thereby improving the accuracy of human health risk estimates. Development of an inhalation reference concentration (RfC) typically involves extrapolation of an effect level observed in a laboratory animal exposure study to a level of exposure in humans that is not expected to… CONTINUE READING
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