Dose-volume considerations in radiosurgery.

@article{Flickinger1991DosevolumeCI,
  title={Dose-volume considerations in radiosurgery.},
  author={J C Flickinger and L D Lunsford and Douglas Kondziolka},
  journal={Stereotactic and functional neurosurgery},
  year={1991},
  volume={57 1-2},
  pages={99-105}
}
Dose-volume effects are very important in radiosurgery. Functional radiosurgery illustrates brain tolerance at the extremes of small volumes and high radiation doses. The risks of radiation necrosis from radiosurgery of arteriovenous malformations (AVMs) and tumors appear to be reasonably well predicted by the integrated logistic formula and the 1% dose-volume isoeffect line for proton beam irradiation. The two main exceptions to this rule are cranial nerves, which appear to be more sensitive… CONTINUE READING

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