Dose-to-Duration Encoding and Signaling beyond Saturation in Intracellular Signaling Networks

  title={Dose-to-Duration Encoding and Signaling beyond Saturation in Intracellular Signaling Networks},
  author={Marcelo Behar and Nan Hao and Henrik G. Dohlman and Timothy C. Elston},
  journal={PLoS Computational Biology},
  pages={2005.0023 - 414}
The cellular response elicited by an environmental cue typically varies with the strength of the stimulus. For example, in the yeast Saccharomyces cerevisiae, the concentration of mating pheromone determines whether cells undergo vegetative growth, chemotropic growth, or mating. This implies that the signaling pathways responsible for detecting the stimulus and initiating a response must transmit quantitative information about the intensity of the signal. Our previous experimental results… CONTINUE READING


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