Dose-titration challenge of young pregnant sheep with Neospora caninum tachyzoites.

@article{Weston2009DosetitrationCO,
  title={Dose-titration challenge of young pregnant sheep with Neospora caninum tachyzoites.},
  author={Jenny F Weston and L Howe and Mark Grey Collett and Ryan Pattison and N. B. Williamson and David M. West and W E Pomroy and Sharifah Salmah Syed-Hussain and Sierra Taylor Morris and P R Kenyon},
  journal={Veterinary parasitology},
  year={2009},
  volume={164 2-4},
  pages={
          183-91
        }
}
Pregnant ewe lambs (7-8 months old at breeding) were inoculated intravenously at 90 days after joining with the ram with 50, 5 x 10(3), 10(6), or 10(8)Neospora caninum tachyzoites and outcomes were compared to a control group. Seroconversion was measured by indirect fluorescent antibody test (IFAT) at fortnightly intervals and by enzyme-linked immunosorbent assay (ELISA) at 28 days post-challenge. Seroconversion (by IFAT) occurred in all animals except for 2 sheep in the lowest dose group… CONTINUE READING

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