Dose study of thymoglobulin during conditioning for unrelated donor allogeneic stem-cell transplantation.

@article{Remberger2004DoseSO,
  title={Dose study of thymoglobulin during conditioning for unrelated donor allogeneic stem-cell transplantation.},
  author={Mats Remberger and B M Svahn and J. -E. Mattsson and Olle Ringd{\'e}n},
  journal={Transplantation},
  year={2004},
  volume={78 1},
  pages={122-7}
}
BACKGROUND Thymoglobulin given before allo-hematopoietic stem-cell transplantation (HSCT) from unrelated donors reduces acute graft-versus-host disease (GvHD), but the optimal dose is unknown. METHOD Four different doses of Thymoglobulin were given to 162 patients with hematologic malignancies undergoing unrelated donor HSCT: 4, 6, 8, and 10 mg/kg. Stem-cell source was bone marrow in 102 cases and peripheral blood stem cells in 60. Conditioning was cyclophosphamide combined with total-body… CONTINUE READING