Dose site reactions and related findings after vaccine administration in safety studies.

  • Paul Baldrick
  • Published 2016 in Journal of applied toxicology : JAT

Abstract

Potential new human vaccines undergo toxicology testing to evaluate local reactogenicity and systemic toxicity. A review of 30 recently published and in-house repeat dose toxicity studies with a variety of vaccines was performed. Species tested were generally rat or rabbit, usually by intramuscular (although occasionally subcutaneous) injection. Results… (More)
DOI: 10.1002/jat.3314

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