Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures.

@article{French2003DoseresponseTO,
  title={Dose-response trial of pregabalin adjunctive therapy in patients with partial seizures.},
  author={Jacqueline A. French and Alan R. Kugler and Jennifer L. Robbins and Lloyd E Knapp and Elizabeth A Garofalo},
  journal={Neurology},
  year={2003},
  volume={60 10},
  pages={1631-7}
}
BACKGROUND Pregabalin is an alpha(2)-delta ligand that has anxiolytic, analgesic, and anticonvulsant properties. OBJECTIVE To establish the efficacy, safety, and tolerability of pregabalin administered twice-daily (BID) without dose titration as adjunctive treatment in patients with partial seizures and to confirm the dose-response relationship. METHODS This 76-center, double-blind, randomized, placebo-controlled, parallel-group study consisted of an 8-week baseline and a 12-week double… CONTINUE READING