Dose-response to inhaled aerosolized prostacyclin for hypoxemia due to ARDS.

  title={Dose-response to inhaled aerosolized prostacyclin for hypoxemia due to ARDS.},
  author={Peter Vernon van Heerden and Anne Barden and Nick Michalopoulos and Max Kishor Bulsara and Brigit L. Roberts},
  volume={117 3},
STUDY OBJECTIVES This study was carried out to determine the efficacy of and dose-response relationships to inhaled aerosolized prostacyclin (IAP), when used as a selective pulmonary vasodilator (SPV) in patients with severe hypoxemia due to ARDS. DESIGN Unblinded, interventional, prospective clinical study. SETTING A general ICU in a university-affiliated, tertiary referral center. PATIENTS Nine adult patients with severe ARDS (lung injury score, > or = 2.5). INTERVENTIONS All patients… CONTINUE READING


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