Dose-response relationships for topically applied antigens.

  title={Dose-response relationships for topically applied antigens.},
  author={Hee Chul Eun and Robin Marks},
  journal={The British journal of dermatology},
  volume={122 4},
Patch-test responses to serially diluted nickel sulphate and potassium dichromate solutions in patients with nickel and chrome sensitivity were assessed by pulsed A-scan ultrasound to determine skin thickness and laser-Doppler flowmeter techniques to evaluate blood flow, as well as clinical scoring. There was a relationship between the dose of antigen and the test responses as measured by ultrasound and laser-Doppler flowmeter techniques in both nickel and chrome sensitive patients. Our data… CONTINUE READING


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