Dose-response relationships for blood cobalt concentrations and health effects: a review of the literature and application of a biokinetic model.

@article{Finley2012DoseresponseRF,
  title={Dose-response relationships for blood cobalt concentrations and health effects: a review of the literature and application of a biokinetic model.},
  author={Brent L Finley and Andrew D. Monnot and Shannon H Gaffney and Dennis J Paustenbach},
  journal={Journal of toxicology and environmental health. Part B, Critical reviews},
  year={2012},
  volume={15 8},
  pages={493-523}
}
Cobalt (Co) is an essential component of vitamin B(12). As with all metals, at sufficiently high doses, Co may exert detrimental effects on different organ systems, and adverse responses have been observed in animals, patients undergoing Co therapy, and workers exposed to respirable Co particulates. Although blood Co concentrations are postulated to be the most accurate indicator of ongoing Co exposure, little is known regarding the dose-response relationships between blood Co concentrations… CONTINUE READING

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