Dose-response relationships between individual nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: a meta-analysis based on individual patient data.

@article{Lewis2002DoseresponseRB,
  title={Dose-response relationships between individual nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) and serious upper gastrointestinal bleeding: a meta-analysis based on individual patient data.},
  author={Stephanie C. Lewis and Michael J. S. Langman and Joan-ramon Laporte and John N. S. Matthews and Michael D Rawlins and B E Wiholm},
  journal={British journal of clinical pharmacology},
  year={2002},
  volume={54 3},
  pages={320-6}
}
AIMS To define by amalgamation of data obtained in contemporaneous case-control studies, the risks associated with individual nonaspirin nonsteroidal anti-inflammatory drugs (NANSAIDs) according to doses used. METHODS Meta-analysis of individual patient data from three retrospective case-control studies using similar data collection protocols was carried out in hospitals in Catalonia, England, Scotland and Sweden. 2472 cases of upper gastrointestinal bleeding and 5877 controls were studied… CONTINUE READING