Dose-response relationship for late functional changes in the rat brain after radiosurgery evaluated by magnetic resonance imaging.

@article{Karger1997DoseresponseRF,
  title={Dose-response relationship for late functional changes in the rat brain after radiosurgery evaluated by magnetic resonance imaging.},
  author={Christian P. Karger and G. H. Hartmann and P. Peschke and J{\"u}rgen Debus and Ursula Hoffmann and Gunnar Brix and Eric W. Hahn and Walter Josef Lorenz},
  journal={International journal of radiation oncology, biology, physics},
  year={1997},
  volume={39 5},
  pages={1163-72}
}
PURPOSE Only few quantitative data are available on late effects in the healthy brain after radiosurgery. An animal model can contribute to systematically investigate such late effects. Therefore, a model applying radiosurgery at the rat brain was established. A long-term (19 months) follow up study with 66 animals after radiosurgery was carried out. METHODS AND MATERIALS In 60 animals, an area in the frontal lobe of the brain was irradiated stereotactically with a 15 MV linac. Different… CONTINUE READING