Dose-response relationship for chemical carcinogenesis by genotoxic agents

  title={Dose-response relationship for chemical carcinogenesis by genotoxic agents},
  author={Werner K. Lutz},
  journal={Sozial- und Pr{\"a}ventivmedizin},
Formation and repair of DNA adducts from genotoxic carcinogens is expected to be proportional to dose as long as the rates of the enzymatic and non-enzymatic activation and inactivation reactions are all proportional to the substrate concentration. Deviations from linearity are expected in situations of induced and saturated kinetics. A sublinear shape of the dose-response curve is always expected at toxic dose levels when regenerative hyperplasia accelerates the fixation and accumulation of… CONTINUE READING