Dose-response pharmacology of intrathecal morphine in human volunteers.

  title={Dose-response pharmacology of intrathecal morphine in human volunteers.},
  author={Peter L. Bailey and S M Rhondeau and Patrick G Schafer and John K H Lu and Barry Timmins and William Foster and Nathan Leon Pace and Theodore H. Stanley},
  volume={79 1},
  pages={49-59; discussion 25A}
BACKGROUND Intrathecal morphine sulfate (ITMS) administration was introduced into clinical practice in 1979. Inadequate information exists delineating ITMS respiratory effects in the dosage range most frequently employed today. This study evaluated 0.2, 0.4, and 0.6 mg ITMS in male volunteers. METHODS Twenty healthy, young, adult male volunteers received 0.0, 0.2, 0.4, or 0.6 mg preservative-free ITMS in an isobaric solution administered at the L3-L4 interspace in a double-blind randomized… CONTINUE READING


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