Dose-response modeling and benchmark calculations from spontaneous behavior data on mice neonatally exposed to 2,2',4,4',5-pentabromodiphenyl ether.

@article{Sand2004DoseresponseMA,
  title={Dose-response modeling and benchmark calculations from spontaneous behavior data on mice neonatally exposed to 2,2',4,4',5-pentabromodiphenyl ether.},
  author={Salomon J Sand and Dietrich von Rosen and Per Eriksson and Anders Fredriksson and Henrik Viberg and Katarina Victorin and Agneta Falk Filipsson},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2004},
  volume={81 2},
  pages={491-501}
}
In this paper the benchmark dose (BMD) method was introduced for spontaneous behavior data observed in 2-, 5-, and 8-month-old male and female C57Bl mice exposed orally on postnatal day 10 to different doses of 2,2',4,4',5-pentabromodiphenyl ether (PBDE 99). Spontaneous behavior (locomotion, rearing, and total activity) was in the present work quantified in terms of a fractional response defined as the cumulative response after 20 min divided by the cumulative response produced over the whole 1… CONTINUE READING

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