Dose-response effects of 8-cyclopropyltheophylline on sleep and wakefulness in rats

@article{Radulovaki2004DoseresponseEO,
  title={Dose-response effects of 8-cyclopropyltheophylline on sleep and wakefulness in rats},
  author={M. Radulova{\vc}ki and R. M. Virus},
  journal={Psychopharmacology},
  year={2004},
  volume={94},
  pages={417-420}
}
  • M. Radulovački, R. M. Virus
  • Published 2004
  • Medicine
  • Psychopharmacology
  • The dose-response effects of the substituted xanthine 8-cyclopropyltheophylline (CPRT) on sleep and wakefulness (W) after intraperitoneal administration to rats were examined by means of simultaneous electroencephalographic (EEG) and electromyographic (EMG) recordings. Doses of 20 and 40 mg/kg CPRT increased W and decreased slow wave sleep (SWS) in rats, indicating CNS stimulant effects. The greatest CNS stimulation was produced by the lowest (20 mg/kg) dose of CPRT examined, which also… CONTINUE READING
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