Dose-response effects of 8-cyclopropyltheophylline on sleep and wakefulness in rats

  title={Dose-response effects of 8-cyclopropyltheophylline on sleep and wakefulness in rats},
  author={M. Radulova{\vc}ki and R. M. Virus},
  • M. Radulovački, R. M. Virus
  • Published 2004
  • Medicine
  • Psychopharmacology
  • The dose-response effects of the substituted xanthine 8-cyclopropyltheophylline (CPRT) on sleep and wakefulness (W) after intraperitoneal administration to rats were examined by means of simultaneous electroencephalographic (EEG) and electromyographic (EMG) recordings. Doses of 20 and 40 mg/kg CPRT increased W and decreased slow wave sleep (SWS) in rats, indicating CNS stimulant effects. The greatest CNS stimulation was produced by the lowest (20 mg/kg) dose of CPRT examined, which also… CONTINUE READING
    3 Citations

    Figures, Tables, and Topics from this paper

    The adenosine kinase inhibitor ABT-702 augments EEG slow waves in rats
    • 25
    Thalamocortical dynamics of sleep: roles of purinergic neuromodulation.
    • 27


    A comparison of the dose response effects of pyrimidine ribonucleosides and adenosine on sleep in rats
    • 21
    The dose-response effects of caffeine on sleep in rats
    • 63
    The effects of adenosine and 2′-deoxycoformycin on sleep and wakefulness in rats
    • 66
    Adenosine analogs and sleep in rats.
    • 237
    Hypnotic effects of deoxycorformycin in rats
    • 65
    Adenosine receptors and behavioral actions of methylxanthines.
    • 655
    • PDF
    Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes
    • 114