Dose response effects of 2-acetylaminofluorene on DNA damage, cytotoxicity, cell proliferation and neoplastic conversion in rat liver.

Abstract

This study measured the effect of precise doses of 2-acetylaminofluorene (AAF) in inducing DNA damage, functional changes and neoplastic conversion in rat liver. Groups of male F344 rats at 9 weeks of age were exposed to cumulative doses of 0.5 or 2.0 mmol AAF per kg body weight given by gavage daily 5 days per week over an 8-week period and maintained with… (More)

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@article{Umemura1993DoseRE, title={Dose response effects of 2-acetylaminofluorene on DNA damage, cytotoxicity, cell proliferation and neoplastic conversion in rat liver.}, author={Takashi Umemura and Kenji Tokumo and Huesyin Sirma and Rolf Gebhardt and Miriam C. Poirier and Gary M Williams}, journal={Cancer letters}, year={1993}, volume={73 1}, pages={1-10} }