Dose-response and time course of specific IgE and IgG after single and repeated topical skin exposure to dry trimellitic anhydride powder in a Brown Norway rat model.

@article{Zhang2002DoseresponseAT,
  title={Dose-response and time course of specific IgE and IgG after single and repeated topical skin exposure to dry trimellitic anhydride powder in a Brown Norway rat model.},
  author={X D Zhang and Dr. Kevin Murray and Daniel M Lewis and Paul D. Siegel},
  journal={Allergy},
  year={2002},
  volume={57 7},
  pages={620-6}
}
BACKGROUND Trimellitic anhydride (TMA)-induced occupational asthma is thought to be associated with its ability to acylate proteins and to induce production of TMA-specific immunoglobulin (Ig)E. Though the respiratory tract is considered to be a major exposure route leading to airway sensitization, the potential role of dermal exposure producing asthmatic sensitization is not known. The present study examines the ability of dry TMA powder to sensitize Brown Norway rats when applied, topically… CONTINUE READING
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