Dose-related potent brain stimulation by the neuropeptide endothelin-1 after intraventricular administration in conscious rats

@article{Chew1995DoserelatedPB,
  title={Dose-related potent brain stimulation by the neuropeptide endothelin-1 after intraventricular administration in conscious rats},
  author={Ben H. Chew and Donald F. Weaver and Paul M. Gross},
  journal={Pharmacology Biochemistry and Behavior},
  year={1995},
  volume={51},
  pages={37-47}
}
Injection of the neuropeptide, endothelin-1 (ET, range of 3-9 pmol), into a lateral ventricle (ICV) of rats produced barrel rolling and other convulsions including ataxia, forelimb and facial clonus, nystagmus, and tonic extension of the tail and hindlimbs. Using the quantitative autoradiographic [14C]deoxyglucose method, we resolved the focal hypermetabolic correlates of the convulsive activity in numerous brain regions. The present study tested whether the effects of ET were dose dependent by… Expand
Role of Endothelin Receptor Subtypes in the Behavioral Effects of the Intracerebroventricular Administration of Endothelin-1 in Conscious Rats
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
The findings indicate that a convulsive i.c.v. dose of ET elicits an NMDA-related stimulatory effect that activates rates of glucose metabolism in several afferent sources and subregions of the cerebellar cortex involved in the regulation of equilibrium, posture, and the visuovestibular system. Expand
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