Dose-related neurocognitive effects of marijuana use

@article{Bolla2002DoserelatedNE,
  title={Dose-related neurocognitive effects of marijuana use},
  author={Karen I. Bolla and K. Brown and Dana A. Eldreth and Kimberly Tate and J. L. Cadet},
  journal={Neurology},
  year={2002},
  volume={59},
  pages={1337 - 1343}
}
BACKGROUND Although about 7 million people in the US population use marijuana at least weekly, there is a paucity of scientific data on persistent neurocognitive effects of marijuana use. [] Key MethodMETHODS A battery of neurocognitive tests was given to 28-day abstinent heavy marijuana abusers. RESULTS As joints smoked per week increased, performance decreased on tests measuring memory, executive functioning, psychomotor speed, and manual dexterity.
View on Publisher
biblioteca.cij.gob.mx
582 Citations
Highly Influential Citations
37
Background Citations
181
Methods Citations
16
Results Citations
40

Tables from this paper

582 Citations

Neurocognitive consequences of marihuana--a comparison with pre-drug performance.
Neurocognition in college-aged daily marijuana users
TLDR
This study comprehensively measured cognitive ability as well as comorbid psychopathology and substance use history to determine the neurocognitive profile associated with young adult marijuana use and found marijuana users were high functioning, demonstrating comparable IQs to controls and relatively better processing speed.
Neuropsychological consequences of regular marijuana use: a twin study
TLDR
The results indicate an absence of marked long-term residual effects of marijuana use on cognitive abilities.
Functional consequences of marijuana use in adolescents
The influence of marijuana use on neurocognitive functioning in adolescents.
TLDR
Adolescents demonstrate persisting deficits related to heavy marijuana use for at least six weeks following discontinuation, particularly in the domains of learning, memory, and working memory, which suggest adolescents appear more adversely affected by heavy use than adults.
Neuropsychological functioning in adolescent marijuana users: Subtle deficits detectable after a month of abstinence
TLDR
The general pattern of results suggested that, even after a month of monitored abstinence, adolescent marijuana users demonstrate subtle neuropsychological deficits compared with nonusers, suggesting that frequent marijuana use during adolescence may negatively influence neuromaturation and cognitive development.
Longitudinal study of cognition among adolescent marijuana users over three weeks of abstinence.
Marijuana use is associated with a reorganized visual-attention network and cerebellar hypoactivation.
TLDR
The greater activation in the active compared with abstinent marijuana users demonstrates a neuroadaptive state in the setting of active marijuana use, while the long-term chronic effect of marijuana on the altered brain network may be reversible with prolonged abstinence.
Age of onset of marijuana use and executive function.
TLDR
Findings suggest that earlier MJ onset is related to poorer cognitive function and increased frequency and magnitude of MJ use relative to later MJ onset, and exposure to MJ during a period of neurodevelopmental vulnerability, such as adolescence, may result in altered brain development and enduring neuropsychological changes.
Combined effects of HIV and marijuana use on neurocognitive functioning and immune status
TLDR
The current study findings extend the literature by demonstrating the complex relationship between HIV status and MJ use on neurocognitive and clinical outcomes.
...
...

References

SHOWING 1-10 OF 52 REFERENCES
The residual cognitive effects of heavy marijuana use in college students.
TLDR
Heavy users displayed significantly greater impairment than light users on attention/executive functions, as evidenced particularly by greater perseverations on card sorting and reduced learning of word lists.
Neuropsychological performance in long-term cannabis users.
TLDR
Some cognitive deficits appear detectable at least 7 days after heavy cannabis use but appear reversible and related to recent cannabis exposure rather than irreversible andrelated to cumulative lifetime use.
Dose-related neurobehavioral effects of chronic cocaine use.
TLDR
Chronic cocaine use is associated with persistent decrements in cognitive function that are most pronounced in heavy users, and knowledge of specific cognitive processing deficits in chronic cocaine users would be useful for designing individually tailored drug treatment programs.
Cognitive functioning of long-term heavy cannabis users seeking treatment.
TLDR
It is confirmed that long-term heavy cannabis users show impairments in memory and attention that endure beyond the period of intoxication and worsen with increasing years of regular cannabis use.
Impaired cognitive performance in drug free users of recreational ecstasy (MDMA)
TLDR
The data suggest that even typical recreational doses of ecstasy are sufficient to cause neurotoxicity in humans, and raise concern that use of ecstasy possibly in conjunction with cannabis may lead to cognitive decline in otherwise healthy young people.
Cognitive correlates of long-term cannabis use in Costa Rican men.
TLDR
Long-term cannabis use was associated with disruption of short-term memory, working memory, and attentional skills in older long-term Cannabis users.
Abstinence symptoms following smoked marijuana in humans
TLDR
This empirical demonstration of withdrawal from smoked marijuana may suggest that daily marijuana use may be maintained, at least in part, by the alleviation of abstinence symptoms.
Memory impairment in abstinent MDMA ("Ecstasy") users
TLDR
The extent of memory impairment correlates with the degree of MDMA exposure and the reduction in brain 5-HT, as indexed by CSF 5-HIAA.
Acute marijuana effects on rCBF and cognition: a PET study
TLDR
Brain regions showing increased r CBF may mediate the intoxicating and mood-related effects of smoking marijuana, whereas reduction of task-related rCBF in temporal lobe cortices may account for the impaired cognitive functions associated with acute intoxication.
The relative contributions of ecstasy and cannabis to cognitive impairment
TLDR
The results suggest that cannabis is an important confound in studies of MDMA-related cognitive impairment, and that previously reported cognitive impairment in MDMA users may have been caused by coincident cannabis use.
...
...