Dose-related gene expression changes in forebrain following acute, low-level chlorpyrifos exposure in neonatal rats.

@article{Ray2010DoserelatedGE,
  title={Dose-related gene expression changes in forebrain following acute, low-level chlorpyrifos exposure in neonatal rats.},
  author={Anamika Ray and Jing ai Liu and Patricia J Ayoubi and Carey Pope},
  journal={Toxicology and applied pharmacology},
  year={2010},
  volume={248 2},
  pages={144-55}
}
Chlorpyrifos (CPF) is a widely used organophosphorus insecticide (OP) and putative developmental neurotoxicant in humans. The acute toxicity of CPF is elicited by acetylcholinesterase (AChE) inhibition. We characterized dose-related (0.1, 0.5, 1 and 2mg/kg) gene expression profiles and changes in cell signaling pathways 24h following acute CPF exposure in 7-day-old rats. Microarray experiments indicated that approximately 9% of the 44,000 genes were differentially expressed following either one… CONTINUE READING

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