Dose-related effects of methadone on QT prolongation in a series of patients with torsade de pointes.

STUDY OBJECTIVE To investigate the relationship between the daily dose of the synthetic opioid methadone and the corrected QT (QTc) interval in a series of methadone-treated patients who developed torsade de pointes. DESIGN Retrospective case series analysis. SETTING Outpatient pain management center and methadone maintenance treatment programs… CONTINUE READING