Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors.

@article{Mortensen1997DoserelatedDO,
  title={Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors.},
  author={Svend Aage Mortensen and A. Leth and Erik Agner and Maria Rohde},
  journal={Molecular aspects of medicine},
  year={1997},
  volume={18 Suppl},
  pages={S137-44}
}
Coenzyme Q10 (ubiquinone) the essential mitochondrial redox-component and endogenous antioxidant, packaged into the LDL + VLDL fractions of cholesterol, has been suggested as an important anti-risk factor for the development of atherosclerosis as explained by the oxidative theory. Forty-five hypercholesterolemic patients were randomized in a double-blind trial in order to be treated with increasing dosages of either lovastatin (20-80 mg/day) or pravastatin (10-40 mg/day) over a period of 18… CONTINUE READING
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