Dose refinements in long-term therapy of rheumatoid arthritis with antimalarials.

@article{Mackenzie1983DoseRI,
  title={Dose refinements in long-term therapy of rheumatoid arthritis with antimalarials.},
  author={Alec Mackenzie},
  journal={The American journal of medicine},
  year={1983},
  volume={75 1A},
  pages={40-5}
}
No eye disease was detected in over 900 rheumatoid arthritis patients treated with less than 4.0 mg/kg per day of chloroquine or less than 6.5 mg/kg per day of hydroxychloroquine for a mean of about seven years. I therefore consider these dosage rates safe, since they are below the threshold of retinal toxicity. This is based on more than 6,000 patient-years of drug exposure. That dosage threshold for retinopathy appears to be 5.1 mg/kg per day for chloroquine and 7.8 mg/kg per day for… CONTINUE READING

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