Dose ranging study of the effects of cholecystokinin in healthy volunteers.

@article{Bradwejn1991DoseRS,
  title={Dose ranging study of the effects of cholecystokinin in healthy volunteers.},
  author={Jacques Bradwejn and Diana Koszycki and Michel S Bourin},
  journal={Journal of psychiatry & neuroscience : JPN},
  year={1991},
  volume={16 2},
  pages={91-5}
}
The authors determined whether response to cholecystokinin-tetrapeptide (CCK-4) was dose-dependent. Healthy volunteers (n = 36) received double-blind injections of either 9 micrograms, 25 micrograms, or 50 micrograms of CCK-4 and placebo in a randomized sequence of injection. Significant dose-related differences were found for the number of symptoms, sum intensity of symptoms and the time until onset of symptoms, but not for the duration of symptoms. The incidence of panic attacks with CCK-4… CONTINUE READING

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