Dose-ranging pharmacokinetics of colistin methanesulphonate (CMS) and colistin in rats following single intravenous CMS doses.

@article{Marchand2010DoserangingPO,
  title={Dose-ranging pharmacokinetics of colistin methanesulphonate (CMS) and colistin in rats following single intravenous CMS doses.},
  author={Sandrine Marchand and Isabelle Lamarche and Patrice Gobin and William Couet},
  journal={The Journal of antimicrobial chemotherapy},
  year={2010},
  volume={65 8},
  pages={
          1753-8
        }
}
OBJECTIVES The aim of this study was to evaluate the effect of colistin methanesulphonate (CMS) dose on CMS and colistin pharmacokinetics in rats. METHODS Three rats per group received an intravenous bolus of CMS at a dose of 5, 15, 30, 60 or 120 mg/kg. Arterial blood samples were drawn at 0, 5, 15, 30, 60, 90, 120, 150 and 180 min. CMS and colistin plasma concentrations were determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS). The pharmacokinetic parameters of CMS and… 
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Pharmacokinetics of Colistin and Colistimethate Sodium After a Single 80‐mg Intravenous Dose of CMS in Young Healthy Volunteers
TLDR
Colistin pharmacokinetics was investigated in young healthy volunteers after a 1‐h infusion of 80 mg (1 million international units (MIU)) of the prodrug colistin methanesulfonate and the values of these pharmacokinetic parameters will serve as reference points for future comparisons with patients' data.
Population Pharmacokinetics of Colistin Methanesulfonate in Rats: Achieving Sustained Lung Concentrations of Colistin for Targeting Respiratory Infections
TLDR
Pulmonary administration of CMS achieves high and sustained exposures of colistin in lungs for targeting respiratory infections and determines the targeting advantage after direct delivery into the lungs.
Pharmacokinetics of four different brands of colistimethate and formed colistin in rats.
TLDR
This is the first study to demonstrate that although different brands of CMS from various parts of the world have similar elemental compositions, they lead to different exposures to the microbiologically active formed colistin.
Substantial Targeting Advantage Achieved by Pulmonary Administration of Colistin Methanesulfonate in a Large-Animal Model
TLDR
Predictions from the pharmacokinetic model indicate that sheep are an advantageous model for translational research, representing a substantial targeting advantage over intravenous administration.
Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys
TLDR
A limited fraction of CMS reaches lungs after nebulization, but higher colistin plasma concentrations were measured and higher intrapulmonary colistIn concentrations were simulated with the Pari LC Star® than with the Eflow Rapid® system.
Differences in pharmacokinetics and pharmacodynamics of colistimethate sodium (CMS) and colistin between three different CMS dosage regimens in a critically ill patient infected by a multidrug-resistant Acinetobacter baumannii.
Gelofusine Ameliorates Colistin-Induced Nephrotoxicity
TLDR
This is the first study demonstrating the protective effect of gelofusine against colistin-induced nephrotoxicity, and highlights the clinical potential of gel ofusine as a safe adjunct for ameliorating the neph rotoxicity and increasing the therapeutic index of polymyxins.
Pharmacokinetics and Pharmacodynamics of Colistin
TLDR
It has become clear that monotherapy with CMS is unlikely to generate plasma colistin concentrations that are reliably efficacious, and combination therapy may be required in order to maximise efficacy and minimise the emergence of resistance.
Quantification of Colistin in Plasma by Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study
TLDR
The developed method to quantify colistin levels in plasma using high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) technique and then apply it in experimental animals (rats) to investigate the pharmacokinetic profile of Colistin in this species demonstrates that it is rapid, sensitive, specific, accurate, precise, and reliable.
Comparison between Colistin Sulfate Dry Powder and Solution for Pulmonary Delivery
TLDR
It is proposed that the difference observed in vivo between the COLI solution and powder could be due to a high local ELF COLI concentration being obtained at the site where the dry particles impact the lung, which can lead to a local increase in COLI Papp, which is associated with a high concentration gradient.
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TLDR
Colistin appeared in plasma soon after administration of CMS, indicating rapid conversion of CMS into colistin, and CMS had a shorter terminal half-life than did colistIn, indicating that the disposition of the colist in generated from CMS was rate-limited by its elimination.
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