Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy

@article{Grant2004DoserangingEO,
  title={Dose-ranging evaluation of the substituted benzamide dazopride when used as an antiemetic in patients receiving anticancer chemotherapy},
  author={Stefan C. Grant and Mark G. Kris and Richard J Gralla and Rebecca A. Clark and Leslie B. Tyson},
  journal={Cancer Chemotherapy and Pharmacology},
  year={2004},
  volume={31},
  pages={442-444}
}
SummaryDazopride, a substituted benzamide structurally related to metoclopramide, is a potent gastric prokinetic agent that prevents cisplatin-induced emesis in animals. Unlike metoclopramide, dazopride has no effect on dopamine receptors and therefore should not produce extrapyramidal side effects. In this dose-ranging trial, 23 patients with cancer receiving chemotherapy known to produce nausea and vomiting received three i.v. infusions of dazopride every 2 h beginning 30 min before the… 

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