Dose-proportional pharmacokinetics of terbinafine and its N-demethylated metabolite in healthy volunteers.

  title={Dose-proportional pharmacokinetics of terbinafine and its N-demethylated metabolite in healthy volunteers.},
  author={John M. Kovarik and St{\'e}phane Kirkesseli and Henri Humbert and Peter Grass and Klaus W. Kutz},
  journal={The British journal of dermatology},
  volume={126 Suppl 39},
The dose-dependency of the pharmacokinetic parameters of terbinafine and its N-demethyl derivative was investigated in a randomized four-way crossover study in healthy volunteers following single oral administrations of 125, 250, 500 and 750 mg of terbinafine. Plasma concentrations of terbinafine and its metabolite were measured by a validated high-performance liquid chromatography (HPLC) method using ultraviolet detection. Concentration data were fitted to a two-compartment model. The… CONTINUE READING


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