Dose optimisation of antibiotics in children: application of pharmacokinetics/pharmacodynamics in paediatrics.

@article{Downes2014DoseOO,
  title={Dose optimisation of antibiotics in children: application of pharmacokinetics/pharmacodynamics in paediatrics.},
  author={Kevin J. Downes and Andrea Hahn and Jason R Wiles and Joshua D. Courter and A. A. T. M. M. Vinks},
  journal={International journal of antimicrobial agents},
  year={2014},
  volume={43 3},
  pages={223-30}
}
The judicious use of antibiotics to combat infections in children relies upon appropriate selection of an agent, dose and duration to maximise efficacy and to minimise toxicity. Critical to dose optimisation is an understanding of the pharmacokinetics and pharmacodynamics of available drugs. Optimal dosing strategies may take advantage of pharmacokinetic/pharmacodynamic (PK/PD) principles so that antibiotic dosing can be individualised to assure effective bacterial killing in patients who have… CONTINUE READING
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