Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats.

@article{Jeong2007DoselinearPO,
  title={Dose-linear pharmacokinetics of oleanolic acid after intravenous and oral administration in rats.},
  author={Dong Won Jeong and Young Hoon Kim and Hui Hyun Kim and Hye Young Ji and Sun Dong Yoo and Won Rack Choi and Soo-Min Lee and C Han and Hye Suk Lee},
  journal={Biopharmaceutics & drug disposition},
  year={2007},
  volume={28 2},
  pages={51-7}
}
The pharmacokinetics of oleanolic acid was evaluated in vitro and in vivo. From Caco-2 cell permeation studies, oleanolic acid was a low permeability compound with no directional effects, suggesting a low in vivo absorption mediated by a passive diffusion. Oleanolic acid was metabolically unstable following incubation with rat liver microsomes in the presence of NADPH. After intravenous injection at doses of 0.5, 1 and 2 mg/kg doses, oleanolic acid showed dose-linear pharmacokinetics as… CONTINUE READING
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