Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial.

@article{Linch1993DoseIW,
  title={Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin's disease: results of a BNLI randomised trial.},
  author={David Christopher Linch and D. J. Winfield and Anthony H. Goldstone and Donald Moir and Barry Hancock and Alex McMillan and Rajesh K. Chopra and Donald J. Milligan and G Vaughan Hudson},
  journal={Lancet},
  year={1993},
  volume={341 8852},
  pages={1051-4}
}
High-dose chemotherapy and radiotherapy with autologous bone-marrow transplantation (ABMT) are increasingly used for the treatment of relapsed and resistant Hodgkin's disease, although there has been no randomised trial of this treatment. The British National Lymphoma Investigation therefore undertook a randomised comparison of high-dose chemotherapy (BEAM = carmustine, etoposide, cytarabine, and melphalan) plus ABMT with the same drugs at lower doses not requiring bone-marrow rescue (mini-BEAM… CONTINUE READING
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